Prakash Vaithyanathan Chennai, India - Brain-fu: 6233
October 31st 2012
The concept of Nuclear Reprogramming is well known in the academic circles of developmental biology. I asked one question to myself and i am seeking answers from all the experts in the world.
Imagine this situation - A cancer cell's nucleus is implanted inside an enucleated zygote. If the zygote succeeds in multiplication then what are the implications - a new form of organism from an evolutionary point of view or the multiplication process probably leads to the creation of cancer stem cells. The inverse problem - what would happen if the zygote's nucleus is transplanted inside a enucleated cancer cell. Could we expect the cytoplasmic contents of the cancer cell do something to the pure zygote nucleus - What are the precise sequence of events - from a non-cancerous nucleus to cancerous one - it will obviously depend upon the cancer that we are working with.
LIKEWISE IF WE REPLACE CANCER CELL'S NUCLEUS BY THE NUCLEUS OF EMBRYONIC STEM CELL OR INDUCED PLURIPOTENT STEM CELL - WHAT WILL BE THE IMPLICATIONS
// edited today - 05/16/2013 by myself: i learned that human embryonic stem cells have been obtained by cloning. i came so close but i used the word zygote in my original posting whereas the US scientists went for egg cell.
Any way my question is this: what would happen if a cancer cell's nucleus is fixd inside the egg cell whose nucleus has been removed.
HEREIN LIES A POTENTIAL KNOWLEDGE MINE
One expert from MIT wrote to me
" Nobody has tried this expt.!"
I am Prakash Vaithyanathan - a British GCE O level Science and Maths Teacher at the M.Ct.M International School chennai India - pvaithyanathan@gmail.com
Co-ideators: Suggested for: EVERYONE Dedicated to: my students Tags: cancer cells nucleus reprogramming zygote |
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